IORT para el tratamiento del cáncer de mama - Medical Technology

Tratamiento

Radioterapia intraoperatoria (IORT) para el tratamiento del cáncer de mama

En los últimos años ha empezado a ganar terreno un nuevo enfoque del tratamiento para el cáncer de mama: los métodos quirúrgicos más radicales se están sustituyendo por cirugías menos invasivas que permiten conservar la mama (BCS). Esta misma tendencia también está llegando a la radioterapia. Los oncólogos se están distanciando de los métodos de tratamiento más convencionales y se están decantando por radioterapias individualizadas adaptadas como la IORT, que tiene en cuenta factores individuales de riesgo de los pacientes y que les ofrece una comodidad muy superior. A diferencia de la radiación tradicional, la radioterapia con ZEISS INTRABEAM^® irradia el lecho tumoral protegiendo el tejido sano circundante. Durante la intervención e inmediatamente después de extirpar el tumor, se realiza una radiación de aproximadamente 30 minutos de duración. El resultado es una reducción del periodo habitual de radioterapia posoperatoria de aproximadamente seis semanas, y en algunos casos puede omitirse en pacientes con perfiles de riesgo bajo.^1,2

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IORT para el tratamiento del cáncer de mama TARGIT frente a RTE

TARGIT Boost

Dosis única TARGIT

Pasos del tratamiento

IORT para el tratamiento del cáncer de mama 1

Paso 1 Se determina la posición del tumor.

IORT para el tratamiento del cáncer de mama 2

Paso 2 Durante la operación se crea un punto de acceso mínimamente invasivo.

IORT para el tratamiento del cáncer de mama 3

Paso 3 Se extirpa quirúrgicamente el tumor.

IORT para el tratamiento del cáncer de mama 4

Paso 4 Se determina el tamaño correcto (Ø) del aplicador y este se posiciona en el lecho tumoral.

IORT para el tratamiento del cáncer de mama 5

Paso 5: El lecho tumoral se irradia localmente durante aproximadamente 30 minutos.

IORT para el tratamiento del cáncer de mama 6

Paso 6 Se retira el aplicador y se cierra la incisión.

TARGIT-A

Ensayo clínico TARGIT-A: "Risk-adapted targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial“. ¹

_{Jayant S Vaidya, Frederik Wenz, Max Bulsara, Jeffrey S Tobias, David J Joseph, Mohammed Keshtgar, Henrik L Flyger, Samuele Massarut, Michael Alvarado, Christobel Saunders, Wolfgang Eiermann, Marinos Metaxas, Elena Sperk, Marc Sütterlin, Douglas Brown, Laura Esserman, Mario Roncadin, Alastair Thompson, John A Dewar, Helle M R Holtveg, Steffi Pigorsch, Mary Falzon, Eleanor Harris, April Matthews, Chris Brew-Graves, Ingrid Potyka, Tammy Corica, Norman R Williams, Michael Baum, en nombre del grupo de ensayo de TARGIT.}

Los resultados de 5 años del ensayo TARGIT-A muestran que el método es equiparable a la radioterapia convencional externa (RTE) del carcinoma ductal invasivo de mama. Tras 5 años de seguimiento no se detectó ninguna diferencia estadística significativa entre el índice de recurrencia local (criterio de evaluación primario) de RTE y de TARGIT. Para los pacientes, las principales ventajas son: reducción de la duración del tratamiento de radioterapia a una sola sesión de aprox. 30 minutos gracias a la radiación dirigida del tejido de interés.

Podcast de "The Lancet“ sobre los resultados de 5 años del ensayo clínico TARGIT-A

Diseño del estudio

Mapa mundial de la técnica IORT para el tratamiento del cáncer de mama (miniatura)

Diseño del estudio

TARGIT-A es el mayor ensayo clínico en el campo de la radiación parcial de tumor mamario (APBI) con pacientes seleccionados aleatoriamente en varios centros. En 33 centros de once países, se ha aplicado radioterapia intraoperatoria dirigida (TARGIT) a 3451 pacientes con buen pronóstico general.

IORT para el tratamiento del cáncer de mama (miniatura)

Características del paciente

Los pacientes seleccionados para el ensayo de TARGIT eran en su mayoría de buen pronóstico pero no mayores, y había un número considerable de pacientes con pronóstico adverso.

Resumen de los resultados

IORT para el tratamiento del cáncer de mama TARGIT RTE (miniatura)

Eficacia de TARGIT en comparación con RTE

Los resultados de los pacientes sin recurrencia local en la mama ipsilateral a los 5 años demuestran que no existe ninguna diferencia significativa al comparar TARGIT combinada con lumpectomía y RTE.

más información

IORT para el tratamiento del cáncer de mama TARGIT RTE: mortalidad (miniatura)

Muertes que no se deben al cáncer de mama

Se redujo de manera significativa el número de muertes no relacionadas con el cáncer de mama con TARGIT en combinación con lumpectomía debido al hecho de que se registraron menos fallecimientos por causas cardiovasculares y otros tipos de cáncer en comparación con RTE.

más información

IORT para el tratamiento del cáncer de mama TARGIT RTE (miniatura de la piel)

Complicaciones en la piel de grado 3 o 4

Con TARGIT, se observaron menos complicaciones en la piel de grado 3 o 4 que con RTE.

No se observaron diferencias significativas en complicaciones relacionadas con lesiones establecidas en los protocolos en cuanto al resultado secundario durante los 6 meses posteriores a la aleatorización.

n = 3451	TARGIT	RTE
Complicaciones relacionadas con lesiones
Hematoma/seroma que requiere más de 3 aspiraciones o cirugía	4	2
Infección de herida que requiere antibióticos intravenosos o cirugía	12	9
Ruptura de la piel/retraso en la cicatrización	3	5
Total	19 (1,1 %)	16 (0,9 %)
	p = 0,599
Complicaciones relacionadas con la radioterapia
Grupo de Oncología y Radioterapia (RTOG) Toxicidad de radioterapia grado 3 o 4	4 (0,2 %)	13 (0,8 %)
	p = 0,029

más información

Conclusión del estudio:

El ensayo clínico aleatorio multicentro confirmó que la Radioterapia intraoperatoria dirigida (TARGIT) con ZEISS INTRABEAM^® es equiparable a la Radioterapia con haz externo (RTE).

"El beneficio más importante del tratamiento TARGIT para las pacientes es que les permite finalizar todo el tratamiento local en el momento de la intervención, con una toxicidad menor para la mama, el corazón y otros órganos. Nuestra investigación respalda el uso de TARGIT en el momento de la lumpectomía, siempre que los pacientes se hayan seleccionado cuidadosamente, y deberá permitir a los pacientes y a sus médicos decidir con mayor conocimiento de causa si individualizar el tratamiento, lo que ahorrará tiempo y dinero y salvará mamas y vidas”.

_{Profesor Jayant Vaidya (doctor en medicina por la FRCS, doctorado)³

Grupo de ensayos clínicos, Departamento de

Ciencias Quirúrgicas e

Intervencionistas, University College

London, Londres (Reino Unido)}

IORT para el tratamiento del cáncer de mama TARGIT-A: resultados de 5 años

Bibliografía

Resumen bibliográfico

1. Tumores cerebrales

Bibliografía más reciente

Cifarelli, C. P., Vargo, J. A., Hack, J., Renz, P. B., Poplawski, L., Jacobson, G. M., … Giordano, F. A. (2019). Intraoperative radiotherapy (IORT) for surgically resected brain metastases: Local control and dosimetric analysis. Journal of Global Oncology, 5(suppl 1), 114.

Cifarelli, C. P., Brehmer, S., Vargo, J. A., Hack, J. D., Kahl, K. H., Sarria-Vargas, G., & Giordano, F. A. (2019). Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study. Journal of Neuro-Oncology, 145(2), 391–397.

Giordano, F. A., Wenz, F., & Petrecca, K. (2016). Rationale for intraoperative radiotherapy in glioblastoma. Journal of Neurosurgical Sciences, 60(3), 350–6.

Giordano, F. A., Brehmer, S., Mürle, B., Welzel, G., Sperk, E., Keller, A., … Wenz, F. (2018). Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial. Neurosurgery.

Sarria, G. R., Sperk, E., Xiaodi, H., Sarria, G. J., Wenz, F., Brehmer, S., … Giordano, F. A. (2019). Intraoperative Radiotherapy for Glioblastoma: An International Pooled Analysis. International Journal of Radiation Oncology*Biology*Physics, 105(1), E107–E108.

Vargo, J. A., Sparks, K. M., Singh, R., Jacobson, G. M., Hack, J. D., & Cifarelli, C. P. (2018). Feasibility of dose escalation using intraoperative radiotherapy following resection of large brain metastases compared to post-operative stereotactic radiosurgery. Journal of Neuro-Oncology, 140(2), 413–420.

Bibliografía adicional

Brehmer, S., Guthier, C. V, Clausen, S., Schneider, F., Schulte, D. M., Benker, M., … Giordano, F. A. (2016). Combined stereotactic biopsy and stepping-source interstitial irradiation of unresectable glioblastoma multiforme. Journal of Neurosurgical Sciences.

Giordano, F. A., Brehmer, S., Muerle, B., Welzel, G., Sperk, E., Schneider, F., … Wenz, F. (2016). Initial Results of a Phase 1/2 Trial on Intraoperative Radiation Therapy (IORT) in Newly Diagnosed Glioblastoma Multiforme (INTRAGO). International Journal of Radiation Oncology, Biology, Physics, 96(2S), E67–E68.

Giordano, F. A., Wenz, F., & Petrecca, K. (2016). Rationale for intraoperative radiotherapy in glioblastoma. Journal of Neurosurgical Sciences, 60(3), 350–6.

Giordano, F. A., Abo-Madyan, Y., Brehmer, S., Herskind, C., Sperk, E., Schneider, F., … Wenz, F. (2014). Intraoperative radiotherapy (IORT)-a resurrected option for treating glioblastoma? Translational Cancer Research, 3(1), 94–105.

Han, X., Fu, B., Wu, M., Zhang, H., Li, D., Zhang, J., … Sun, S. (2014). Intraoperative Radiotherapy with INTRABEAM in primary brain tumors after resection: Preliminary reports of 26 cases. Neuro-Oncology, 16.

Kalapurakal, J. A., Goldman, S., Stellpflug, W., Curran, J., Sathiaseelan, V., Marymont, M. H., & Tomita, T. (2006). Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy). International Journal of Radiation Oncology Biology Physics, 65(3), 800–808.

Weil, R. J., Mavinkurve, G. G., Chao, S. T., Vogelbaum, M. a, Suh, J. H., Kolar, M., & Toms, S. a. (2015). Intraoperative radiotherapy to treat newly diagnosed solitary brain metastasis: initial experience and long-term outcomes. Journal of Neurosurgery, 122(4), 825–832.

2. Cáncer de mama

Alvarado, M. D., Mohan, A. J., Esserman, L. J., Park, C. C., Harrison, B. L., Howe, R. J., … Ozanne, E. M. (2013). Cost-effectiveness analysis of intraoperative radiation therapy for early-stage breast cancer. Annals of Surgical Oncology, 20(9), 2873–80.

Harris, E. E. R., & Small, W. (2017). Intraoperative Radiotherapy for Breast Cancer. Frontiers in Oncology, 7(December), 1–8.

Holmes, D. R. (2015). Intraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for Primetime. The Breast Journal, 21(2), 181–184.

Holmes, D. R. (2017). Early complications after intraoperative radiotherapy revisited. Journal of Surgical Oncology, 115(7), 779–781.

Keshtgar, M. R. S., Vaidya, J. S., Tobias, J. S., Wenz, F., Joseph, D., Stacey, C., … Baum, M. (2011). Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible. International Journal of Radiation Oncology*Biology*Physics, 80(1), 31–38.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013). Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial. Breast Cancer Research and Treatment, 140(3), 519–525.

Kolberg, H.-C., Loevey, G., Akpolat-Basci, L., Stephanou, M., Fasching, P. A., Untch, M., … Vaidya, J. S. (2017). Targeted intraoperative radiotherapy tumour bed boost during breast-conserving surgery after neoadjuvant chemotherapy. Strahlentherapie Und Onkologie, 193(1), 62–69.

Kolberg, H.-C., Lövey, G., Akpolat-Basci, L., Stephanou, M., Fasching, P., Untch, M., Hoffmann, O., Bulsara, M., Vaidya, J., & Liedtke, C. (2017). Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer. Breast Care, 12(5), 318–323.

Malter, W., Kirn, V., Richters, L., Fridrich, C., Markiefka, B., Bongartz, R., … Kraemer, S. (2014). Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences. International Journal of Breast Cancer, 1–6.

Picot, J., Copley, V., Colquitt, J. L., Kalita, N., Hartwell, D., Bryant, J. (2015). The INTRABEAM® photon radiotherapy system for the adjuvant treatment of early breast cancer: A systematic review and economic evaluation. Health Technology Assessment, 19(69), 1–190.

Rivera, R., Banks, A., Casillas-Lopez, A., Rashtian, A., Lewinsky, B., Sheth, P., … Holmes, D. R. (2016). Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast. The Breast Journal, 22(1), 63–74.

Sedlmayer, F., Reitsamer, R., Wenz, F., Sperk, E., Fussl, C., Kaiser, J., … Fastner, G. (2017). Intraoperative radiotherapy (IORT) as boost in breast cancer. Radiation Oncology, 12(1), 23.

Sperk, E., Welzel, G., Keller, A., Kraus-Tiefenbacher, U., Gerhardt, A., Sütterlin, M., Wenz, F. (2012). Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomised phase III trial TARGIT A. Breast Cancer Research and Treatment, 135(1), 253–260.

Sperk, E., Astor, D., Keller, A., Welzel, G., Gerhardt, A., Tuschy, B., … Wenz, F. (2014). A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer. Radiation Oncology, 9(1), 154.

Sperk, E. (2019). First per Protocol Analysis of the Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer: Targit E(lderly). International Journal of Radiation Oncology*Biology*Physics, 105(1), S8.

Tallet, A., Racadot, S., Boher, J.-M., Cohen, M., Barrou, J., Houvenaeghel, G., Gutowski, M., Delmond, L., & Lemanski, C. (2020). The actual benefit of intraoperative radiation therapy using 50 kV x-rays in early breast cancer: A retrospective study of 676 patients. The Breast Journal.

Tang, A., Cohan, C. M., Beattie, G., Cureton, E. L., Svahn, J. D., Lyon, L. L., Kelly, J. F., & Shim, V. C. (2021). Patients older 65 years with early breast cancer prefer intraoperative radiation as a locoregional treatment choice. Annals of Surgical Oncology.

Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Keshtgar, M., … Baum, M. (2014). Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. The Lancet, 383(9917), 603–613.

Vaidya, J. S., Bulsara, M., Wenz, F., Joseph, D., Saunders, C., Massarut, S., … Baum, M. (2015). Pride, prejudice, or science: Attitudes towards the results of the TARGIT-A trial of targeted intraoperative radiation therapy for breast cancer. International Journal of Radiation Oncology Biology Physics, 92(3), 491–497.

Vaidya, J. S., Bulsara, M., Wenz, F., Coombs, N., Singer, J., Ebbs, S., … Baum, M. (2016). Reduced mortality with partial breast irradiation for early breast cancer – a meta-analysis of randomised trials. International Journal of Radiation Oncology*Biology*Physics, 1–7.

Vaidya, J. S., Bulsara, M., Baum, M., Wenz, F., Massarut, S., Pigorsch, S., Alvarado, M., Douek, M., Saunders, C., Flyger, H. L., Eiermann, W., Brew-Graves, C., Williams, N. R., Potyka, I., Roberts, N., Bernstein, M., Brown, D., Sperk, E., Laws, S., … Tobias, J. S. (2020). Long-term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial. BMJ, 370, m2836.

Vaidya, J. S., Bulsara, M., Baum, M., Tobias, J. S., Wenz, F., Massarut, S., Pigorsch, S., Alvarado, M., Douek, M., Saunders, C., Flyger, H. L., Eiermann, W., Brew-Graves, C., Williams, N. R., Potyka, I., Roberts, N., Bernstein, M., Brown, D., Sperk, E., … Joseph, D. J. (2021). Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment. British Journal of Cancer, December 2020, 1–6.

Vaidya, J. S., Bulsara, M., Baum, M., Wenz, F., Massarut, S., Pigorsch, S., Alvarado, M., Douek, M., Saunders, C., Flyger, H., Eiermann, W., Brew-Graves, C., Williams, N. R., Potyka, I., Roberts, N., Bernstein, M., Brown, D., Sperk, E., Laws, S., … Tobias, J. S. (2021). New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer. British Journal of Cancer, 1–10.

3. Tumores gastrointestinales

Guo, S., Reddy, C. A., Kolar, M., Woody, N., Mahadevan, A., Deibel, F., … Suh, J. H. (2012). Intraoperative radiation therapy with the photon radiosurgery system in locally advanced and recurrent rectal cancer: retrospective review of the Cleveland clinic experience. Radiation Oncology, 7(1), 110.

Kim, J. W., Cho, Y., Kim, H. S., Choi, W. H., Park, J. S., & Lee, I. J. (2019). A phase II study of intraoperative radiotherapy using a low-energy x-ray source for resectable pancreatic cancer: a study protocol. BMC Surgery, 19(1), 31.

Ma, L., Qiang, J., Yin, H., Lin, L., Jiao, Y., Ma, C., Li, X., Dong, L., Cui, J., Wei, D., Sharma, A. M., Schwartz, D. L., Gu, W., & Chen, H. (2020). Low-kilovolt x-ray intraoperative radiotherapy for pT3 locally advanced colon cancer: a single-institution retrospective analysis. World Journal of Surgical Oncology, 18(1), 132.

Polkowski, W. P., Skórzewska, M. (2014). Intraoperative Radiotherapy with Low-Energy Photons in Rectal Cancer Recurrence. (M. Keshtgar, K. Pigott, & F. Wenz, Eds.), Targeted Intraoperative Radiotherapy in Oncology. Berlin, Heidelberg: Springer Berlin Heidelberg.

Potemin, S., Uvarov, I., Vasilenko, I. (2015). Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases. Transl Cancer Res, 4(2), 189–195.

Potemin, S., Kübler, J., Uvarov, I., Wenz, F., & Giordano, F. (2020). Intraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapy. Radiation Oncology, 15(1), 1–7.

Skórzewska, M., Mielko, J., Kurylcio, A., Romanek, J., Polkowski, W. P. (2016). Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: a single centre retrospective study. Współczesna Onkologia, 20(1), 52–57.

Susko, M., Lee, J., Salama, J., Thomas, S., Uronis, H., Hsu, D., … Palta, M. (2016). The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer. Annals of Surgical Oncology.

Xue, W., Wang, S., Zhao, Z., Li, Y., Shang, A., Li, D., Yang, J., Wang, T., & Wang, M. (2020). Short-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: A single center experience. World Journal of Surgical Oncology, 18(1), 1–8.

4. Tumores de cabeza y cuello

De Felice, F., Musio, D., Tombolini, V. (2016). Intraoperative radiation therapy (IORT) in recurrent head and neck cancer. Oral Oncology, 55(March), e1.

Kyrgias, G., Hajiioannou, J., Tolia, M., Kouloulias, V., Lachanas, V., Skoulakis, C., … Bizakis, I. (2016). Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review. Medicine, 95(50), e5035.

Münter, M. W., Köppen, U., Ramuscak, A., Sittel, C., Wegner, N. (2015). Intraoperative radiotherapy (IORT) in the treatment of head and neck cancer. Transl Cancer Res, 4(2), 178–181.

Roopashri, G., Baig, M. (2013). Current advances in radiotherapy of head and neck malignancies. Journal of International Oral Health, 5(6), 119–23.

5. Sarcoma de tejido blando y cáncer de piel no melanocítico

Bodner, W. R., Hilaris, B. S., Alagheband, M., Safai, B., Mastoras, C. A., Saraf, S. (2003). Use of low-energy X-rays in the treatment of superficial nonmelanomatous skin cancers. Cancer Investigation, 21(3), 355–362.

Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., Green, W. H. (2012). Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. Journal of the American Academy of Dermatology, 67(6), 1235–41.

Sarria, G. R., Petrova, V., Abo-Madyan, Y., Wenz, F., Hohenberger, P., Sperk, E., & Giordano, F. A. (2019). Intraoperative Radiotherapy with Low Energy x-Rays for Primary and Recurrent Soft-Tissue Sarcoma. International Journal of Radiation Oncology*Biology*Physics, 105(1), E810.

Tward, J.D., Anker, C, J,. Gaffney, D.K., Bowen, G. . (2012). Radiation Therapy and Skin Cancer. Modern Practices in Radiation Therapy, 207–246.

6. Metástasis vertebrales

Bludau, F., Reis, T., Schneider, F., Clausen, S., Wenz, F., Obertacke, U. (2015). Kyphoplastie kombiniert mit intraoperativer Radiotherapie (Kypho-IORT). Der Radiologe, 55(10), 859–867.

Bludau, F., Welzel, G., Reis, T., Schneider, F., Sperk, E., Neumaier, C., Ehmann, M., Clausen, S., Obertacke, U., Wenz, F., & Giordano, F. A. (2018). Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases. The Spine Journal, 18(5), 776–781.

Bludau, F., Welzel, G., Reis, T., Abo-Madyan, Y., Sperk, E., Schneider, F., Clausen, S., Ruder, A. M., Obertacke, U., Ghaly, M. M., Wenz, F., & Giordano, F. A. (2019). Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study. BMC Cancer, 19(1), 430.

Kayser, R., Ender, S. A., Asse, E., Wilhelm, E., Adler, F., Schmidt, R., … Bludau, F. (2013). Kyphoplastie in Kombination mit intraoperativer Radiotherapie. Der Orthopäde, 42(9), 765–771.

Miglierini, P., Dam-Hieu, P., Key, S. (2014). Kypho-IORT: the first French treatment. Translational Cancer Research, 3(1).

Mohme, M., Riethdorf, S., Dreimann, M., Werner, S., Maire, C. L., Joosse, S. A., Bludau, F., Mueller, V., Neves, R. P. L., Stoecklein, N. H., Lamszus, K., Westphal, M., Pantel, K., Wikman, H., & Eicker, S. O. (2017). Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases. Nature Scientific Reports, 7(1), 7196.

Schmidt, R., Wenz, F., Reis, T., Janik, K., Bludau, F., Obertacke, U. (2012). Kyphoplasty and intra-operative radiotheray, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approach. International Orthopaedics, 36(6), 1255–1260.

7. Física médica

Culberson, W. S., Davis, S. D., Gwe‐Ya Kim, G., Lowenstein, J. R., Ouhib, Z., Popovic, M., Waldron, T. J., Safigholi, H., Simiele, S. J., & Rivard, M. J. (2020). Dose‐rate considerations for the INTRABEAM electronic brachytherapy system: Report from the American association of physicists in medicine task group no. 292. Medical Physics, 47(8).

Eaton, D. J., Gonzalez, R., Duck, S., Keshtgar, M. (2011). Radiation protection for an intra-operative X-ray device. The British Journal of Radiology, 84(1007), 1034–1039.

Eaton, D. J. (2012). Quality assurance and independent dosimetry for an intraoperative x-ray device. Medical Physics, 39(11), 6908.

Goubert, M., Parent, L. (2015). Dosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applications. Physica Medica, 31(3), 224–232.

Herskind, C., Griebel, J., Kraus-Tiefenbacher, U., & Wenz, F. (2008). Sphere of Equivalence-A Novel Target Volume Concept for Intraoperative Radiotherapy Using Low-Energy X Rays. International Journal of Radiation Oncology Biology Physics, 72(5), 1575–1581.

Shaikh, M. Y., Burmeister, J., Scott, R., Kumaraswamy, L. K., Nalichowski, A., & Joiner, M. C. (2020). Dosimetric evaluation of incorporating the revised V4.0 calibration protocol for breast intraoperative radiotherapy with the INTRABEAM system. Journal of Applied Clinical Medical Physics, 21(2), 50–59.

Sethi, A., Emami, B., Small, W., & Thomas, T. O. (2018). Intraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric Considerations. Frontiers in Oncology, 8(March), 1–10.

Schneider, F., Clausen, S., Jahnke, A., Steil, V., Bludau, F., Sütterlin, M., … Wenz, F. (2014). Radiation protection for an intraoperative X-ray source compared to C-arm fluoroscopy. Zeitschrift für medizinische Physik, 24(3), 243–251.

Schneider, F., Clausen, S., Thölking, J., Wenz, F., Abo-Madyan, Y. (2014). A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report. Journal of Applied Clinical Medical Physics / American College of Medical Physics, 15(1), 4502.

Sethi, A., Chinsky, B., Gros, S., Diak, A. (2015). Tissue inhomogeneity corrections in low-kV intra-operative radiotherapy (IORT). Translational Cancer Research, 4(2), 182–188.

Schneider, F., Greineck, F., Clausen, S., Mai, S., Obertacke, U., Reis, T., & Wenz, F. (2011). Development of a Novel Method for Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases (Kypho-IORT). International Journal of Radiation Oncology*Biology*Physics, 81(4), 1114–1119.

8. Radiobiología

Belletti, B., Vaidya, J. S., D’Andrea, S., Entschladen, F., Roncadin, M., Lovat, F., … Massarut, S. (2008). Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding. Clinical Cancer Research, 14(5), 1325–1332.

Emami, B., Woloschak, G., Small Jr, W. (2015). Beyond the linear quadratic model : intraoperative radiotherapy and normal tissue tolerance. Transl Cancer Res, 4(2), 140–147.

Herskind, C., Ma, L., Liu, Q., Zhang, B., Schneider, F., Veldwijk, M. R., & Wenz, F. (2017). Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects. Radiation Oncology (London, England), 12(1), 24.

Herskind, C., Wenz, F. (2014). Radiobiological aspects of intraoperative tumour-bed irradiation with low-energy X-rays ( LEX-IORT ). Transl Cancer Res, 3(1), 3–17.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013). Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial. Breast Cancer Research and Treatment, 140(3), 519–525.

Kulcenty, K., Piotrowski, I., Rucinski, M., Wroblewska, J. P., Jopek, K., Murawa, D., & Suchorska, W. M. (2020). Surgical Wound Fluids from Patients with Breast Cancer Reveal Similarities in the Biological Response Induced by Intraoperative Radiation Therapy and the Radiation-Induced Bystander Effect-Transcriptomic Approach. International Journal of Molecular Sciences, 21(3).

Liu, Q., Schneider, F., Ma, L., Wenz, F., Herskind, C. (2013). Relative Biologic Effectiveness (RBE) of 50 kV X-rays Measured in a Phantom for Intraoperative Tumor-Bed Irradiation. International Journal of Radiation Oncology*Biology*Physics, 85(4), 1127–1133.

Minafra, L., & Bravatà, V. (2014). Cell and molecular response to IORT treatment. Translational Cancer Research, 3(1), 32–47.

Sologuren, I., Rodríguez-gallego, C., & Lara, P. C. (2014). Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects. Transl Cancer Res, 3(1), 18–31.

Wang, M., Maier, P., Wenz, F., Giordano, F. A., & Herskind, C. (2013). Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line. Journal of Neuro-Oncology, 115(3), 323–331.

9. Calidad de vida y resultados estéticos

Alvarado, M. D., Conolly, J., Park, C., Sakata, T., Mohan, A. J., Harrison, B. L., … Ozanne, E. M. (2014). Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery. Breast Cancer Research and Treatment, 143(1), 135–140.

Andersen, K. G., Gärtner, R., Kroman, N., Flyger, H., Kehlet, H. (2012). Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomised trial. The Breast, 21(1), 46–49.

Corica, T., Nowak, A. K., Saunders, C. M., Bulsara, M., Taylor, M., Vaidya, J. S., … Joseph, D. J. (2016). Cosmesis and breast-related quality of life outcomes following intra-operative radiotherapy for early breast cancer - a sub-study of the TARGIT-A trial. International Journal of Radiation Oncology*Biology*Physics.

Corica, T., Nowak, A. K., Saunders, C. M., Bulsara, M. K., Taylor, M., Williams, N. R., Keshtgar, M., Joseph, D. J., & Vaidya, J. S. (2018). Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial. Radiation Oncology, 13(1), 68.

Corica, T., Saunders, C. M., Bulsara, M. K., Taylor, M., Joseph, D. J., & Nowak, A. K. (2019). Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment. European Journal of Cancer Care, March 2018, e12985.

Coombs, N. J., Coombs, J. M., Vaidya, U. J., Singer, J., Bulsara, M., Tobias, J. S., … Vaidya, J. S. (2016). Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT. BMJ Open, 6(5).

Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., … Hall, P. (2013). Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. New England Journal of Medicine, 368(11), 987–998

Elsberger, B., Romsauerova, A., Vinnicombe, S., Whelehan, P., Brown, D. C., Dewar, J. A., … Evans, A. (2014). Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy. European Journal of Surgical Oncology, 40(2), 163–167.

Holmes, D. R., & Zimmerman, R. (2017). Intraoperative radiotherapy: Patient selection, management, and follow-up. Journal of Surgical Oncology, 116(7), 824–830.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013). Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial. Breast Cancer Research and Treatment, 140(3), 519–525.

Malter, W., Kirn, V., Mallmann, P., & Kraemer, S. (2014). Oncoplastic breast reconstruction after IORT. Translational Cancer Research, 3(1), 74–82.

Welzel, G., Boch, A., Sperk, E., Hofmann, F., Kraus-Tiefenbacher, U., Gerhardt, A., … Wenz, F. (2013). Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomised phase III trial TARGIT-A. Radiation Oncology, 8(1), 9.

Williams, N., Kurylcio, A., Jankiewicz, M., Romanek, J., Polkowski, W., Michalopoulos, N., & Keshtgar, M. (2017). Cosmetic outcome after breast conserving surgery and either external beam or intraoperative radiotherapy for early breast cancer: Objective assessment of patients from a randomized controlled trial in Lublin, Poland. European Journal of Cancer, 6, 867–870.

10. IORT general

Eaton, D. J. (2015). Electronic brachytherapy—current status and future directions. The British Journal of Radiology, 88(1049), 20150002.

Harris, E. E. R., & Small, W. (2017). Intraoperative Radiotherapy for Breast Cancer. Frontiers in Oncology, 7(December), 1–8.

Holmes, D. R. (2015). Intraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for Primetime. The Breast Journal, 21(2), 181–184.

Wenz, F. (2017). Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting. Annals of Surgical Oncology, Aug.

11. Directrices y recomendaciones

Aetna. (2015). Intraoperative Radiation Therapy (IORT).

Cardoso, F., Kyriakides, S., Ohno, S., Penault-Llorca, F., Poortmans, P., Rubio, I. T., Zackrisson, S., & Senkus, E. (2019). Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 374, 1–77.

NHS. (2018). National Institute for Health and Care Excellence Intrabeam - radiotherapy system for adjuvant treatment of early breast cancer. Technology Appraisal Guidance. Retrieved January 31, 2018

NCCN. (2020). NCCN Clinical Practical Guidelines in Oncology - Cancer Type: Breast, Colon, Rectal, H&N...

Niyazi, M., Brada, M., Chalmers, A. J., Combs, S. E., Erridge, S. C., Fiorentino, A., … Belka, C. (2016). ESTRO-ACROP guideline “target delineation of glioblastomas.” Radiotherapy and Oncology, 118(1), 35–42.

Onkologie, L. (2020). Leitlinienprogramm Onkologie: S3-Leitlinie Früherkennung, Diagnose, Therapie und Nachsorge des Mammakarzinoms, Version 4.3.

Polgár, C., Limbergen, E. Van, Pötter, R., Kovács, G., Polo, A., Lyczek, J., … Strnad, V. (2010). Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group. Radiotherapy and Oncology, 94(3), 264–273.

Smith, B. D., Bellon, J. R., Blitzblau, R., Freedman, G., Haffty, B., Hahn, C., Halberg, F., Hoffman, K., Horst, K., Moran, J., Patton, C., Perlmutter, J., Warren, L., Whelan, T., Wright, J. L., & Jagsi, R. (2018). Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Practical Radiation Oncology, 8(3), 145–152.

Tsao, M. N., Rades, D., Wirth, A., Lo, S. S., Danielson, B. L., Gaspar, L. E., Sperduto, P. W., Vogelbaum, M. A., Radawski, J. D., Wang, J. Z., Gillin, M. T., Mohideen, N., Hahn, C. A., & Chang, E. L. (2012). Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline. Practical Radiation Oncology, 2(3), 210–225.

Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Saunders, C., Brew-Graves, C., Potyka, I., Morris, S., Vaidya, H. J., Williams, N. R., & Baum, M. (2016). An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial). Health Technology Assessment, 20(73), 1–188.

Cáncer de mama

Radioterapia intraoperatoria (IORT) para el tratamiento del cáncer de mama

Pasos del tratamiento

Diseño del estudio

Diseño del estudio

Características del paciente

Resumen de los resultados

Eficacia de TARGIT en comparación con RTE

Muertes que no se deben al cáncer de mama

Complicaciones en la piel de grado 3 o 4

Conclusión del estudio:

Resumen bibliográfico

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